#5189 THE ASSOCIATION BETWEEN CD86 +1057G>A POLYMORPHISM AND ACUTE KIDNEY ALLOGRAFT REJECTION AMONG EGYPTIAN PATIENTS
نویسندگان
چکیده
Abstract Background and Aims T-cell mediated immune response is crucial in kidney transplantation plays an important role allograft rejection. . CD86 a costimulatory molecule that participates the regulation of lymphocytes activation. Single nucleotide polymorphisms (SNPs) located this gene have been studied with inconsistent results. The aim study was to examine association between (rs1129055:G/A) polymorphism development acute renal rejection among Egyptian patients. Method In non- concurrent cohort study, we included group 50 transplant recipients diagnosed by (AR) (which defined clinical diagnosis, elevated serum creatinine >30% basal line absence other pathology including infection, urinary tract obstruction, artery stenosis or calcineurin toxicity responded treatment immunosuppression confirmed positive biopsy graded according BANFF classification) another matched without AR all 100 patients were genotyped direct sequencing for CD 86 TaqMan genotyping assay. Results genotypic frequencies rs1129055 SNP 72% GG, 28% AG 0% AA while no it 66% 30% 4% AA. genotype A allele at position +1057 more frequent (4% 23.4%, respectively) compared those showing (0% 16.2%, respectively). odds weren`t statistically significant either dominant recessive model (P = 0.665 0.475 Conclusion These results suggest +1057G>A may provide nonsignificant protection against
منابع مشابه
CD86 +1057G>A polymorphism and susceptibility to acute kidney allograft rejection.
INTRODUCTION CD86 is a costimulatory molecule that participates in the regulation of T-cell lymphocytes activation. Thus, we examined a genetic marker on the CD86 gene in kidney transplant outcome. MATERIALS AND METHODS In our retrospective study, 168 kidney allograft recipients were genotyped by direct sequencing. Patients were classified into 2 groups of 29 human leukocyte antigen (HLA)-ide...
متن کاملEvaluation of CTLA-4, CD28 and CD86 Genes Polymorphisms in Acute Renal Allograft Rejection among Tunisian Patients
متن کامل
Rejection of the kidney allograft.
Copyright © 2010 Massachusetts Medical Society. The science of kidney transplantation has progressed considerably in the past half-century largely because of an improved understanding of the role of the immune system in allograft rejection, the disentanglement of the molecular mechanisms underlying graft failure, and better management of immunosuppression.1,2 Rejection has always been the major...
متن کاملPrevention of kidney allograft rejection using anti-CD40 and anti-CD86 in primates.
BACKGROUND Costimulation blockade has been proposed to induce allograft tolerance. We combined an antagonist anti-CD40 monoclonal antibody (mAb) with an antagonist anti-CD86 mAb in a rhesus monkey kidney allograft model. We chose this combination because it leaves CD80-CD152 signaling unimpaired, allowing for the down-regulatory effect of CD152 signaling to take place through this pathway. ME...
متن کاملAnalysis of proteomic and acute kidney allograft rejection in rat
1 Department of Urology, the First Affiliated Hospital, Chongqing Medical University, Chongqing, 400016, China. 2 Department of Emergency, the First Affiliated Hospital, Chongqing Medical University, Chongqing, 400016, China. 3 Department of Laboratory Medicine, the First Affiliated Hospital, Chongqing Medical University, Chongqing, 400016, China. *Corresponding author. E-mail: wu_yi2012@gmail....
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Nephrology Dialysis Transplantation
سال: 2023
ISSN: ['1460-2385', '0931-0509']
DOI: https://doi.org/10.1093/ndt/gfad063d_5189